Rich Piana stated this was the best cycle he had ever taken. The initial dose of clomiphene citrate will be 25 mg (po, pill by mouth) every other day. The store will not work correctly in the case when cookies are disabled. Inhibition of pituitary gonadotropin secretion in men by T is principally mediated by aromatization to estrogen (E), which inhibits hypothalamic secretion of GnRH. To provide the best experiences, we use technologies like cookies to store and/or access device information. Enclomiphene (Androxal), in development by Repros Therapeutics Inc, is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. Many patients, both men and women, have asked me over the years what can they do to boost their natural production of Androgens (Testosterone and DHEA). and then stop the Clomid until you speak with your doctor. 2) Cures Gynecomastia or 'Man Boobs'. Why was there a paradoxical response to HCG ? Copyright (c) 2012-13 Jeffrey Dach MD All Rights Reserved. I am so grateful that I came across this article. What is everyones opinion on taking clomid and test c here? 4) Raises Sperm Count. Clomid for men stimulates the bodys own production of testosterone. In a cycle nobody uses clomid to maintain HPTA. So while your hypothalamus and pituitary are suppr. hCG mimics LH and is more potent and longer lasting. More specifically, males with low testosterone who also want to maintain or enhance their fertility. The patient wished to retain fertility which contra-indicated the use of Testosterone preparations. Mean patient age was 43. Male hypogonadism usually is treated with testosterone replacement to return testosterone levels to normal. Comparison was made between baseline and post-treatment variables, and multivariable analysis was conducted to define predictors of successful response to CC. Clomid is used (off label) to help increase mens testosterone levels more naturally. While traditional testosterone replacement therapy produces good results, it has the downside of basically turning off the bodys memo to make testosterone because its artificially produced by the medication. How can they determine how high clomid is raising test levels when you are injecting testosterone? 2005 Nov;44(11):836-9. are known to interact with The dosage range is 12.5mg 50mg per day. 3 - Then remove the clomid and go with testosterone ONLY for six weeks - run the same labs at the same laboratory. Why human growth hormone was ever banned from sports. The drugs used for this purpose are the following: This will be started at visit 2, week 0 of the study following diagnosis of low baseline testosterone (serum total testosterone <350 ng/dl in men <55 years, <300 ng/dl in men 55-65 years). 1998 HCG Originally it was used to increase ovulation and improve fertility in women. Innovative Mens Health is now proud to offer Bio-identical Testosterone Pellet Therapy! Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you. Clomid for men can help improve several aspects of male fertility, including low testosterone levels, hormone ratios, sperm count, and it has even been shown to improve pregnancy rates. Epub 2007 Feb 8. Thanks a lot. No alcohol/food interactions were found. Testosterone is a male sex hormone. \, Clomid Clomiphene for Males Increases LH FSH Testosterone, Image upper left: Pituitary feedback control of LH, FSH and Testosterone from Estrogen (E2). According to the Centers for Disease Control and Prevention, both a male and a female . In a study published in 2012, conducted by Veterans Affairs in Seattle, Washington, researchers found that in men with low testosterone levels, testosterone treatment was associated with decreased mortality compared with no testosterone treatment.5. CONCLUSIONS: Low dose clomiphene citrate is effective in elevating serum testosterone levels and improving the testosterone/estradiol ratio in men with hypogonadism. Testosterone Pellets are implanted beneath the skin on the lower back two to three times per year. Enclomiphene demonstrates promise in the management of secondary hypogonadism associated with obesity, metabolic syndrome and, possibly, infertility, and should undergo placebo-controlled, randomized clinical trials for these indications. Select patients with hypogonadotropic hypogonadism may respond to treatment with clomiphene citrate. Fertil Steril. It In 2, 1 with primary and another with secondary hypogonadism, testosterone levels returned to normal after phlebotomy and were accompanied by a return of normal sexual function. A total of This increase is not as high as pellets or injections but it can make a big difference depending on how low you are. Hypogonadism in hemochromatosis: reversal with iron depletion. Most men, when initially prescribed, will google the medication and find that its used for women and fertility. Many men find that using clomid for testosterone replacement therapy is just as effective as traditional TRT.Clomid has been around for quite some time. If judged by the testis volume, 52 patients (81.2%) were effective and 12 patients were ineffective. Dispelling the Myth that Testosterone Causes Prostate Cancer, Testosterone and Prostate Cancer -Dispelling the Myth that Testosterone Causes Prostate Cancer, L-carnitine Deficiency And Testosterone Therapy. Not consenting or withdrawing consent, may adversely affect certain features and functions. There have been rare reports of vision changes. Testosterone is in the drug class androgens and anabolic steroids. Clomid PCT Guidelines. Many people view testosterone as a tough guy hormone. We use physical exam and blood test results to determine if you are a possible candidate for Testosterone Replacement Therapy at Innovative Mens Health clinic. 954-792-4663 The test result does not show common signs of low Testosterone. Hormone Testing: Blood, Urine or Saliva? This explains in some, the paradoxical response to HCG which may initially raised testosterone levels. Schedule a consultation with our doctor today. Clomid is meant to force your body to maintain its sperm production. JavaScript is disabled. Results taking Clomid and Letrozole together w/ PCOS and Anovulation (Clomid 100mg, Letrozole 7.5mg) nursettc member. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes. Treatment needs to be monitored as too high a dose can paradoxically . Do you have a decrease in strength and/or endurance? IMH's medical doctors can prescribe FDA-approved testosterone injections, pellets, or gels in Seattle, Bellevue, Lynnwood, and Federal Way. This drug for men fertility, boost your sperm production and balances your hormone. PATIENTS AND METHODS:Serum T, oestradiol and luteinizing hormone (LH) were measured in patients who were treated with CC for over 12 months. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. J Clin Endocrinol Metab. Howles CM, Tanaka T, Matsuda T. Department of Global Product Development, Merck Serono International SA, Geneva Switzerland. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Pingback: Tamoxifen for Low Testosterone in Males - Jeffrey Dach MD, Pingback: Clomid Nolvadex And Testosterone Stimulation, Pingback: Low Testosterone Ng/ml | testosterone booster side effects, How do men get it? If a man is taking any form of supplemental testosterone (TRT), then his pituitary will go through a process called negative feedback resulting in the shutting down of LH. In some . The compound also exhibited an unanticipated favorable effect on fasting plasma glucose; this result has been accompanied by rapidly accumulating evidence from other researchers for a bidirectional relationship between low serum testosterone and obesity/metabolic syndrome (syndrome X) in men. This is not a complete list of side effects and others may occur. Upper left image : cropped portions of an anonymous body builder, courtesy of wikimedia commons. The subjects were randomized to one of two doses of enclomiphene citrate (12.5-mg or 25-mg), 1% topical testosterone, or placebo. Short-term clinical safety data for enclomiphene have been satisfactory and equivalent to safety data for testosterone gels and placebo. Methods: This randomized phase IIB study enrolled 124 men with a morning serum T level of <250 ng/dL on 2 occasions. Oestrogen levels may be elevated owing to aromatization of testosterone. The Journal of Clinical Endocrinology & Metabolism January 1, 2011 vol. Fertility is preserved. 1995 February; 162(2): 158160. 18) www.jstage.jst.go.jp/article/endocrj/advpub/0/0702070033/_pdf RESULT(S): Ten men who were evaluated for infertility were diagnosed with HH. I dont see how you can recover HPTA during TRT or a cycle and use clomid. So you may want to discuss a bit more with your doc to better understand the intention of each of these medications. - Clomid and HCG to treat low testosterone for UK TRTclomid together with testosterone - clomid for low sperm count -. Oddly enough, doctors often prescribe it to help stimulate ovulation in women, but it's now attracting attention as a testosterone replacement therapy for males. Analysis of baseline and follow-up serum levels of testosterone and estradiol levels were performed. Four had Kallmanns syndrome, four idiopathic HH, and two panhypopituitarism. Demographic, comorbidity, treatment and Androgen Deficiency in Aging Men (ADAM) score data were also recorded. [Endocrine effects of doping with androgenic anabolic steroids]. While testosterone replacement is the most common treatment, it can paradoxically lead to infertility, and may be a less physiologic therapy for patients with secondary hypogonadism due to pituitary dysfunction. Apart from that, a man taking this medication will enjoy the following benefits: Increase in sexual desire (high libido) Growth in muscle mass. Clomid For Men With Low Testosterone 2012 Nov;110(10):1524-8. Clomid will work as well. The target testosterone level was 550 50 ng/dL. Hypogonadism is a prevalent problem, increasing in frequency as men age. Six weeks later, the patient reported feeling like my old self with improved energy, libido and mood. Men over 35 years of age were over six times as likely to develop pyospermia as men under 35 years of age (P < .05). Use in males is "off-label". I prefer to keep it simple. Clomid for Men with Low Testosterone Part One by Jeffrey Dach MD, Low Testosterone From Pain Pills by Jeffrey Dach MD, Clomid For Men With Low Testosterone, Part Two, Testosterone Benefits, and the PSA part one, Exogenous testosterone: a preventable cause of male infertility, http://eje-online.org/content/155/4/513.long, http://www.ncbi.nlm.nih.gov/pubmed/16990650, jcem.endojournals.org/content/96/1/38.full#ref-28, www.ncbi.nlm.nih.gov/pmc/articles/PMC1022657/?page=1, www.ncbi.nlm.nih.gov/pmc/articles/PMC2360778/?tool=pubmed, www.jstage.jst.go.jp/article/endocrj/advpub/0/0702070033/_pdf, Clomiphene Clomid Adverse Side Effects Part Three by Jeffrey Dach MD - Jeffrey Dach MD, Clomid for men with low testosterone part four, Testosterone and the Stock Market Mania - Jeffrey Dach MD. Three of the four men with adult-onset idiopathic HH responded to CC alone with increases in testosterone, FSH, and LH. Press question mark to learn the rest of the keyboard shortcuts. The technical storage or access that is used exclusively for statistical purposes. There were no major side effects recorded and the presence of a varicocele did not have an impact on the response to CC. Decreased fat mass and obesity prevention. Link to this article:http://wp.me/P3gFbV-1j. It inhibits the ability of the aromatase enzyme to convert testosterone to estrogen. Anxiety about obtaining or maintaining an erection during sexual intercourse may lead some men to have less control over ejaculation. Testosterone Replacement Therapy in Seattle. Rest assured, long-term use of clomid in males is safe. The drug reset this to a higher level, allowing more LH, FSH which then stimulated testosterone production. RESULTS: Spontaneous nonbacterial pyospermia developed in CC-treated men [14.3%] at rate nearly twice that observed in controls [7.4%]. Very simply, the pituitary gland in the brain is the director of testicular function. At Innovative Mens Health, were dedicated to helping men reverse issues related to aging. Dosage can be adjusted based on any side effects, lab results, and an overall improvement in the T-effect. Just like testosterone replacement therapy, Clomid must be prescribed and monitored by your doctor. The Male of the species has this same estrogen receptor in the hypothalamus which controls LH and FSH production. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. 9) www.ncbi.nlm.nih.gov/pubmed/17007848 Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. 2013 Oct;17(Suppl1):S32-S34. 1984 Nov;101(5):629-32. 3) Increases Muscle Mass. HCG for reversing anabolic steroid abuse, 15) www.ncbi.nlm.nih.gov/pmc/articles/PMC2360778/?tool=pubmed www.ncbi.nlm.nih.gov/pubmed/9538490. I can help you navigate through all the complexities of hormone replacement and would be happy to answer any questions you might have. No, not Clomid. Typically that type of fatigue coupled with low libido brings a young man into the doctors office for a check-up. By the first follow-up visit (4-6 weeks), the mean testosterone level rose to 610.0 +/- 178.6 ng/dL (P < 0.00001). It's simple; Exogenous testosterone via the negative feedback look shuts down HPTA; meaning that your Hypothalamus, Pituitary and Testicles don't work anymorethat normal. If it sees a high testosterone level, it stops telling the testes to produce testosterone. For when you're coming off a harsh steroid or testosterone cycle. Results: The mean age was 30.2 5.6. I know it's been a time but What dose of clomid did your doctor recommended along with what dose of t? So Clomid will act on estrogen receptors in the brain and block them. The monthly cost of Testim 1% (5 gm daily) is $270, Androgel 1% (5 gm daily) is $265, and CC (50 mg every other day) is $83. Clomid can be used for short periods with trt to bring testicles size up and luck start negative feed back for a bit. The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician patient relationship. Traditionally, men diagnosed with low testosterone were started on testosterone replacement therapy (TRT or ART). George B1, Bantwal G. Endocrine management of male subfertility. Indian J Endocrinol Metab. In one study the administration of tamoxifen, 20 mg/day for 10 days, to normal males produced a moderate increase in luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol levels, comparable to the effect of 150 mg of clomiphene citrate (Clomid). August 2018 in Trying to Get Pregnant . Source Male Sexual and Reproductive Medicine Programme, Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. The following information is provided to help you understand the role of the previously female-dominated drug, Clomid, in testosterone replacement for that group of males. The drug clomiphene (Clomid) is the safest therapy doctors have to increase testosterone levels while preserving fertility, Moss said. 5) jcem.endojournals.org/content/96/1/38.full#ref-28 Thanks again. But some men have erectile dysfunction, or ED. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur. Estrogen acts as a stop stop stop signal to the pituitary telling it to cease making LH. Chua ME1, Escusa KG, Luna S, Tapia LC, Dofitas B, Morales M. Revisiting oestrogen antagonists (clomiphene or tamoxifen) as medical empiric therapy for idiopathic male infertility: a meta-analysis. Andrology. Use of this supplement might increase levels of androgen and have a steroid effect. Clomid cannot and will not increase LH or increase testicular size while on TRT. Conclusion: Clomiphene for men with low testosterone is a viable option for younger males who wish to maintain fertility. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Alabama, Birmingham, Alabama 35249-7333, USA. SETTING: The outpatient endocrinology clinic of a university tertiary referral center. I understand the reasons why many say this does not work because of the physiological mechanics of what exogenous testosterone does and how this would counteract what Clomid does, but I do know Clomid IS WORKING to keep my testicles from shrinking. are known to interact with Our study demonstrates that CC is efficacious after 3 years of therapy. Eur J Endocrinol. 6. RESULTS: patients mean (standard deviation [sd]; range) age was 29 (3; 22-37) years. Assessment of androgen status should be accomplished in all men with ED. Most physicians are not willing to go out past a year or two. 8. Clomid is a pill taken daily. 64 men with central hypogonadism were recruited in this study, including 19 patients with Kallmann syndrome, 41 patients with idiopathic hypogonadotrophic hypogonadism (IHH) and 4 patients with hypogonadism after brain surgery. Subjective improvements were also demonstrated. Tan RS, Vasudevan D. Department of Family and Community Medicine, University of Texas Health Sciences Center, Houston, Texas 77030, USA. For those with lower than normal age-matched levels of testosterone treatment directed at normalizing testosterone with clomiphene citrate is a viable alternative to giving androgen supplements. C Bickelman, L Ferries, and R P Eaton Department of Medicine, University of New Mexico School of Medicine, Albuquerque, USA. For Part Two, Click Here. CONCLUSION(S): Exercise-induced hypogonadotropic hypogonadism exists as a clinical entity among male endurance athletes, and CC may provide a safe and effective treatment option for males with debilitating hypogonadism related to endurance exercise. However, a more natural method for replacing testosterone that produced similar results was found. Testosterone Replacement Therapy (TRT) is the replacement of the naturally declining Testosterone hormone in men. Clomid (clomiphene citrate) uses a different approach to increase testosterone and spermatogenesis. Not only does it improve muscle mass, but it also supports a vibrant sexual experience. www.naturalmedicine101.com The level of sex hormone binding globulin is suppressed. I did have an increase in estrogen so we are now working on that. OBJECTIVE: To review the management of male hypogonadotropic hypogonadism (HH) and evaluate the efficacy of clomiphene citrate (CC). 7. It may also not work, especially in patients over 60 and those with compound medical issues. Clomid can present side effects in some people, but I cannot say I have experienced any of these side effects. For younger males who wish to maintain or enhance fertility this is a good option. Pingback: Low Testosterone And Infertility | healthtooth.com, wow what a great Article you shared with the public. Impotence related to anabolic steroid use in a body builder.Response to clomiphene citrate. 10. Your low testosterone levels test and low testosterone symptoms should be correlated when youre considering low testosterone treatment. Testicular function remained normal thereafter on no treatment. CONCLUSION( S): Select patients with adult-onset idiopathic forms of HH may benefit from a trial of clomiphene citrate. It has few, if any, side effects and this is usually dose-related. As such, a man should not stop taking the medication unless there is no improvement by the fourth month of treatment. You may report side effects to FDA at 1-800-FDA-1088. also fosters the production of red blood cells, boosts mood, and aids cognition. Fertil Steril. 2. Strengthening the immune function. The only way to bypass the negative feedback within the pituitary and increase testicular suze while on TRT is by taking HCG, which is a . Paradoxical Response with Lower Testosterone Levels. Thanks for writing and sharing. Feb 1, 2022. Some clients may even see a larger increase. 1) Testosterone undecanoate 1000mg (Nebido) 2) Clomiphene Citrate 50mg tablets daily. Granted, too much of anything is unhealthy, including testosterone. Telegram Testosterone (free and total), sex hormone binding globulin, oestradiol, luteinizing hormone and follicle stimulating hormone were measured at baseline and during treatment on all patients. The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network. 2010 Jan;7(1 Pt 1):269-76. 2009 Feb;12(2):109-19. Pingback: Got my blood work today, any advice? There are many myths about low testosterone. Read More. Facebook. This results in an increase of the body's. own testosterone production. Also, the lower the testosterone level, the longer it may take to see the benefits of Clomid versus traditional testosterone therapy. We can usually achieve a 100% increase in T levels with Clomid. . The negative feedback initiated by having testosterone present will override any stimulation that clomid can provide. We offer both in-clinic and remote telemedicine consultations worldwide. To learn more about low testosterone diagnosis and treatment options, make an appointment at Austin Urology Institute at 512.694.888 with a provider to discuss symptoms and explore options. Decreased responses also occurred in men with diabetes, hypertension, coronary artery disease, and multiple medication use. Clomid in Men With Low Testosterone With and Without Prior Treatment. Testosterone Benefits and PSA Part Two. Because of preferential conversion of testosterone to estrogen in some men, elevated estrogen levels may require the addition of an aromatase inhibitor such as anastrazole (also called Arimidex). Ann Intern Med. 16) www.ncbi.nlm.nih.gov/pubmed/16316564 Though its much more than simply to grow muscles. Treatment with Clomid (clomiphene 25 mg tablet daily) was started. Subjectively, there was an improvement in all questions (except loss of height) on the ADAM questionnaire. Austin men's clinic austin urology institute Best urologist in austin Bladder cancer symptoms Central tx urology dr. shaw austin iud vs vasectomy low t center Austin mens health Austin North austin urology testosterone replacement therapy near me urological cancer surgeon texas urologic health urologist austin tx Urologist in austin vasectomy austin vasectomy doctor vasectomy infection vasectomy reversal vasectomy texas. This stimulates the production of GnRH, gonadotropins. To be diagnosed with hypogonadism requires more than just having low levels of testosterone in the blood. Men with low testosterone have a 33% higher risk of death from any cause than men with normal testosterone levels regardless of age, physical activity, or lifestyle. Clomid, stimulates the hypophysis to release more gonadotropin so that. A total of 164 drugs are known to interact with testosterone. 2009 Dec;18(12):1947-55. It's the battle for supreme first-line fertility treatment medications when trying to conceive isn't going as easy as your junior high sex-ed class made it out to be.. Clomid (Clomiphene citrate) has been the most commonly prescribed oral fertility drug for over 50 years. 6/64 patients underwent spermatorrhea and 2 patient were found to have spermatogenesis. Pingback: Hypogonadal Males | newhopedrugrehabnj.com, Pingback: Health Benefits of Peruvian Maca - Jeffrey Dach MD. An experienced doctor can help you connect the dots and find the low testosterone test that will help diagnose the cause of your health concern. This image is an illustration only, and not an actual patient in any clinic. No adverse events were reported by any patients. Its clogs receptors in hypothalamus which respond to estrogen and limit Gnrh if enough estrogen is binding. Additionally, it is a pill typically taken every day, so no need to be poked with needles or cover oneself in gels.The downsides to Clomid therapy are that it is rarely covered by insurance as it is an off label use of the medication (however it is generic and very affordable). Nolvadex (Tamoxifen) - 60 capsules, each dosed at 20 mg @ $80. Moderately clinically significant. This report displays the potential drug interactions for the following 2 drugs: No interactions were found between Clomid and testosterone. DESIGN: Case report. Use Clomid together with testosterone? 1. Clomid is most commonly prescribed to men who have infertility that also have low testosterone levels. In a 2006 report in the European Journal of Endocrinology by Dr Rochira from Italy showed that the feedback of gonadotropins (GnRH from the hypothalamus) is regulated by estrogens that come from the aromatization of testosterone. Recent Yearly Bloodwork- some help please! We recommend seeing our doctor for the diagnosis. Originally it was used to increase ovulation and improve fertility in women. We also expla. 2006 Oct;155(4):513-22. S It takes time for a man to see fertility results from Clomid. In clinical trials conducted to date, enclomiphene demonstrated significant efficacy in the physiological restoration of testosterone levels in males with secondary hypogonadism. This prospective study is the largest to date assessing both the objective hormone response to CC therapy as well as the subjective response based on a validated questionnaire. It might make things easier should you decide to discontinue. www.drdach.com This also explains why testes shrink a bit on TRT. The good news is that ED can be treated quickly, at any age with the Innovative approach. Fatigue that cant be cured with sleep is one of the biggest indicators of low testosterone. Vince provided a good link about which leads to a thread discussing using HCG to preserve fertility and testicle size while on TRT. Eight patients were azoospermic, and two were oligospermic on presentation. CONCLUSIONS:For male patients with the central hypogonadism, hCG and hCG plus HMG can promote the pubertal development and maturation of second sex characteristics, as well as enhance the physical strength; in some patients both androgen production and spermatogenesis can be achieved. It reminds the testes that they do have a job to do other than just making testosterone. Kaminetsky J, Hemani ML. Clomiphene citrate (CC) may be used as an alternative treatment in these patients with hypogonadism when maintenance of fertility is desired. Email this report to a friend, doctor, or patient. Anadrol, Trenbolone and Testosterone Cycle. Since these conditions are more prevalent with aging, chronic disease may be a more important determinant of sexual dysfunction. anybody got a woman pregant here while being on TRT 1+ year? I usually start my patients at 25mg per day and then retest all blood values after 6 weeks, adjusting dosing as needed. It takes 90 to 108 days from the time that sperm is produced in the testicles until it is ejaculated. To report a case of symptomatic hypogonadism induced by the abuse of multiple steroid preparations that was subsequently reversed by clomiphene. 05.11.2012. Enclomiphene constitutes the trans-stereoisomer of clomiphene citrate, a drug that has been widely prescribed for several decades for the treatment of female ovulatory dysfunction. 2010 Jan;7(1 Pt 1):269-76. Outcomes of clomiphene citrate treatment in young hypogonadal men. J Sex Med. Each patient is different and the response will vary depending on current testosterone level. Anti-Aging Medicine 25 years experience. It also focuses on lifestyle activities like exercise and nutrition for raising testosterone levels naturally or anything else related to testosterone the substance. Study Type Therapy (case series) Level of Evidence 4 Whats known on the subject? Clomiphene citrate is safe and effective for long-term management of hypogonadism.
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