J. Med. Int. doi: 10.1242/dev.135434, Bulik-Sullivan, B., Finucane, H. K., Anttila, V., Gusev, A., Day, F. R., Loh, P. R., et al. Stability and flexibility of epigenetic gene regulation in mammalian development. (2003). Nat. doi: 10.1007/s00439-013-1283-6, Beldie, L., Walker, B., Lu, Y., Richmond, S., and Middleton, J. PLoS One 12:e0176566. Noggin and retinoic acid transform the identity of avian facial prominences. 7:10815. doi: 10.1038/ncomms10815, PubMed Abstract | CrossRef Full Text | Google Scholar, Aelion, C. M., Airhihenbuwa, C. O., Alemagno, S., Amler, R. W., Arnett, D. K., Balas, A., et al. Estimating the sex-specific effects of genes on facial attractiveness and sexual dimorphism. There is no one answer to this question as everyone has their own unique facial features.
facial WebIn the combinations sc/sg and st/sd , Irish now uses sc and st , while Scottish Gaelic uses sg and both sd and st , despite there being no phonetic difference between the two languages. The Ceili Dances consist of quadrilles, reels, jigs and long or round dances. A genome-wide association study identifies five loci influencing facial morphology in Europeans. Evol. et al., 2018) with differential DNA methylation, but contrastingly there is no clear evidence for an association between prenatal alcohol exposure and DNA methylation (Sharp et al., 2018). There's also some more darker features in some people, like black hair and brown eyes. 90, 478485. doi: 10.1016/j.ajodo.2004.06.037, Kayser, M. (2015). J. Anat. 33:245. BMJ Open 5:e009027. J. Environ. WebThese are the major differences between an Irish and a Scottish accent. MSc thesis, Cardiff University, Cardiff. With increased sample sizes, improved understanding of shared genetic influences on human traits and advancement in techniques there is likely to be significant further progress in the next 6 years. Med. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Facial morphological differences relating to ancestry are well-characterized when comparing individuals from distinct populations, but distinct differences remain even within more ancestrally homogeneous populations. The first wave of genetic studies of craniofacial Mendelian traits were based on linkage or candidate gene studies of genetic loci known to be involved in craniofacial development or genetic syndromes affecting the face. doi: 10.1002/ajmg.a.35515, Xu, C., Qu, H., Wang, G., Xie, B., Shi, Y., Yang, Y., et al. Nat. A population-based cross-sectional study of the association between facial morphology and cardiometabolic risk factors in adolescence. The evolution of human skin coloration. doi: 10.1016/j.ajhg.2011.12.021, Peng, S., Tan, J., Hu, S., Zhou, H., Guo, J., Jin, L., et al. 115, 5173. Caserta, D., Graziano, A., Lo Monte, G., Bordi, G., and Moscarini, M. (2013). Exploring the underlying genetics of craniofacial morphology through various sources of knowledge. 15, 335346.
scottish vs irish facial features facial features Nature 414, 909912. Although, it is known that the PAX3 influences the prominence of the bridge of the nose it is more challenging to know to what extent this influences adjacent facial regions in each individual. There are several important reasons for exploring the genetics of normal-range variation in facial morphology. (2014). doi: 10.1016/bs.ctdb.2015.09.001, Mellion, Z. J., Behrents, R. G., and Johnston, L. E. Jr. (2013). Previously published studies that have identified gene-phenotype associations which provides evidence of associations for complex facial traits which can be integrated into prediction models. The authors would like to thank Dr. Ryan Arathimos (University of Bristol) for advice on a draft of the manuscript. BMJ Open.
Irish Facial Features Irish Features Firstly we have to put in mind that that both the Celtic and Germanic are a Northern and Central European people. Thus as Europeans from those regi Armstrong, D. A., Green, B. There are words each language use for their own, like wee for the Scottish and aye for the Irish. Sci. Not too strongly different. The British Keltic type. And the Anglo-Saxon type. Physically speaking there's no stark contrast. Infact I've seen self Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. 13:e1006616. The size and heterogeneity of these data sets pose new challenges to efficiently and effectively, store, simplify and analyze the relative interactions and influences for a large number of face shape variables. Aesthet Surg. Judging by the looks of all the peoples known to have a strong Celtic background, and according to some historical sources, Id say that Celts were A blind accuracy assessment of computer-modeled forensic facial reconstruction using computed tomography data from live subjects. Bioessays 29, 145154. BMC Genomics 19:481. doi: 10.1186/s12864-018-4865-9, Chaitanya, L., Breslin, K., Zuniga, S., Wirken, L., Pospiech, E., Kukla-Bartoszek, M., et al. Indeed, a previous study demonstrated that a major risk locus for non-syndromic cleft lip/palate (nsCL/P), in a non-coding interval, is involved in the regulation of gene expression in the developing murine face (Uslu et al., 2014) while another study found some evidence that nsCL/P genetic variants may influence nsCL/P risk via changes in DNA methylation and gene expression (Howe et al., 2018b). Changes in face topography from supine-to-upright position-And soft tissue correction values for craniofacial identification. Int. Most modern Celts have dark hair and a red beard. PLoS Genet. Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals. Scottish English can best be summed up as being an accent that is the perfect combination of Gaelic roots, Scots phonology and an English lexicon. Early growth genetics consortium. Most Scottish people have brown hair, Touch device users, explore by touch or with swipe gestures. 128, 424430. Identification of five novel genetic loci related to facial morphology by genome-wide association studies. doi: 10.1371/journal.pone.0014821, Boehringer, S., Van Der Lijn, F., Liu, F., Gnther, M., Sinigerova, S., Nowak, S., et al. A number of Scottish people have a wavy texture to their hair. Am. scottish vs irish facial featurescbc news nl here and now. Rep. 7:2441. doi: 10.1038/s41598-017-02721-0. J. Orthod.
Difference Between Scottish and Irish Yes. Very different. I thought I was in a foreign country going to Warwick compared to Scots. Us scots have softer faces, wider eyes and foreheads, (2016). doi: 10.1016/j.forsciint.2013.10.021, Sidlauskas, M., Salomskiene, L., Andriuskeviciute, I., Sidlauskiene, M., Labanauskas, Z., Vasiliauskas, A., et al. 55, 2731. Face shape differs in phylogenetically related populations. (For the sense of a primitive stone tool, see the separate article, later.) The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (2016). Previous studies have used DNA methylation in blood as a proxy for methylation in lip and palate tissues. Curr. Department of Human Genetics, Faculty of Medicine, KU Leuven, Belgium, Children's Hospital of Philadelphia, United States. The final difference between Scotch and Irish whiskey is the taste. Rev. doi: 10.1016/j.bjps.2014.01.003, Uslu, V. V., Petretich, M., Ruf, S., Langenfeld, K., Fonseca, N. A., Marioni, J.C., et al. Scientists have merged dozens of famous faces to create what they call the most beautiful faces in the world. The PAX3 gene is associated with the distance between the mid-endocanthion point and surface nasion with a mean distance of 17.5 mm with differing axis values up to 6.7 mm (x), 17.7 mm (y), and 18.9 mm (z). doi: 10.1126/science.1243518, Hemani, G., Tilling, K., and Smith, G. D. (2017). Hu, D., and Helms, J. Table 2 highlights that genetic variants influencing facial morphology can have pleiotropic effects on parts of the body independent to the brain and surrounding craniofacial structures (e.g., cardiovascular, endocrine, gastro-intestinal, central nervous, musculo-skeletal and uro-genital systems). Genome-wide association study of facial morphology reveals novel associations with FREM1 and PARK2. doi: 10.1093/ije/dyy032. Sci. 42, 17691782. Sharp, G. C., Arathimos, R., Reese, S. E., Page, C. M., Felix, J., Kpers, L. K., et al. Previous studies have suggested that facial features such as attractiveness (Little et al., 2001; Fink and Penton-Voak, 2002), hair color (Wilde et al., 2014; Adhikari et al., 2016; Field et al., 2016; Hysi et al., 2018), eye color (Little et al., 2003; Wilde et al., 2014; Field et al., 2016) and skin pigmentation (Jablonski and Chaplin, 2000, 2010; Wilde et al., 2014; Field et al., 2016) may influence mate choice and/or have been under historical selection. The Argyle has fewer buttons and is suitable for daytime and evening use. Lond. 81, 351370. Most epigenetic changes are transient and not generally heritable. A., Mattern, B. C., Claes, P., McEcoy, B., Hughes, C., and Shriver, M. D. (2017). The aim will be to continually develop and advance existing computerized tools and algorithms to solve these complex problems and this will require a multidisciplinary and internationally based team. There is some evidence to suggest that there are additive genetic effects on nose shape involving SOX9, DCHS2, CASC17, PAX1, RUNX2, and GL13 and chin shape, SOX9 and ASPM. (2012). Genetic interactions or epistasis may also explain the low levels of variance recorded. Modeling 3D facial shape from DNA. (2014). doi: 10.1038/ng.3570, Pirttiniemi, P. M. (1994). Hu, N., Strobl-Mazzulla, P. H., and Bronner, M. E. (2014). genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. The collective use of these techniques to identify the various facial features will increase the robustness of linking the DNA to a likely suspect/candidate. Arch. WebThe website faceresearch.org allows you to participate in short online psychology experiments looking at the traits people find attractive in faces and voices. bioRxiv. Biol. doi: 10.1006/jhev.2000.0403, Jablonski, N. G., and Chaplin, G. (2010). doi: 10.1016/j.fsigen.2016.01.010, Tsagkrasoulis, D., Hysi, P., Spector, T., and Montana, G. (2017). Some people believe that Scottish and Irish DNA is similar, while others believe that it is not. doi: 10.1038/nrg3706. Further detail is required on the heritability of facial features with particular attention to inherited pathways of specific facial features in homogenous populations and populations with significant admixture. doi: 10.1111/j.1601-6343.2007.00386.x, Marcucio, R., Hallgrimsson, B., and Young, N. M. (2015). Adv. doi: 10.1038/ng.2971, Van der Beek, M. C., Hoeksma, J. 415, 171187. Fine tuning of craniofacial morphology by distant-acting enhancers. doi: 10.1097/01.scs.0000171847.58031.9e, Farkas, L. G., Tompson, B. D., Katic, M. J., and Forrest, C. R. (2002). Differential methylation is associated with non-syndromic cleft lip and palate and contributes to penetrance effects. Eur. Peter Forsberg (hockey player) (Notice how his eyes are higher up. There are over 25,000 registered Scottish tartans. Forensic DNA Phenotyping: predicting human appearance from crime scene material for investigative purposes. In addition, genetic and environmental factors will have subtle influences on the face. Eur. J. J. Orthod. A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. 2. Forensic age prediction for saliva samples using methylation-sensitive high resolution melting: exploratory application for cigarette butts. The gene regulatory systems are complex and numerous and detailing these regulatory mechanisms has been the goal of the NIH Roadmap Epigenomics Project whereby next generation sequencing technologies (e.g., ChiP seq) are employed to map DNA methylation, histone modifications, chromatin accessibility in a variety of research media such as, animal models (mouse, chicken, zebrafish, frog, and primates) and stem cells and regulated human fetal tissues (Hochheiser et al., 2011; Roosenboom et al., 2016; Van Otterloo et al., 2016). 3:e002910. Heritability studies have provided insight into the possible genetic and environmental contributions to face shape. 1. doi: 10.1111/1467-8721.00190, Freund, M. K., Burch, K., Shi, H., Mancuso, N., Kichaev, G., Garske, K. M., et al. Genet. SR, ES, SL, and LH wrote the section Craniofacial Shape Gene Discovery. Forensic Sci. The role of enhancers modifying histones, chromatin states are key for normal range craniofacial development and relative position of the various craniofacial tissues. (2017). Behav. Lond. J. Hum. Multiethnic GWAS reveals polygenic architecture of earlobe attachment. Tartan. Polygenic risk scores, LD score regression (to reduce confounding biases Bulik-Sullivan B.K. doi: 10.1002/bdrc.20117, Shrimpton, S., Daniels, K., de Greef, S., Tilotta, F., Willems, G., Vandermeulen, D., et al. doi: 10.1371/journal.pgen.1004572, Schmidt, E., and Kornfeld, J. W. (2016). 6. The genome is comprised of 3.2 billion nucleotides wrapped in octomeric units of histones (chromatin). Clin.
The Look of the Irish: - The Washington Post Mol. Dev. 22, e1e4. Ancestry and physical appearance are highly related; it is often possible to infer an individuals recent ancestry based on physically observable features such as facial structure and skin color. Facial masculinity does not appear to be a condition-dependent male ornament in humans and does not reflect MHC heterozygosity. Perceptions of epigenetics.
Is anyone else able to easily spot an Irish person by facial features Celt (people 3. doi: 10.1371/journal.pgen.1007501, Howe, L. J., Richardson, T. G., Arathimos, R., Alvizi, L., Passos-Bueno, M.-R., Stanier, P., et al. WebIrish-Scots (Scottish Gaelic: ireanneach-Albais) are people in Scotland who have traceable Irish ancestry.Although there has been migration from Ireland (especially Ulster) to Britain for millennia permanently changing the historic landscape of Scotland forever, Irish migration to Scotland increased in the nineteenth century, and was highest following the Oral Radiol. Dev. Surg. J. Craniofac. In addition, the individual facial traits have yielded impressive levels of significance using a relatively small number of subjects (Evans, 2018). Biol. (2006). (2013). They just released a fascinating study which aligns many pictures of individuals from every country and created composite images of what the average face would look like. doi: 10.1038/s41588-018-0100-5, Idemyor, V. (2014). 48, 709717. 12:e1006174. Even with relatively long acquisition times for some photogrammetric, MRI, CT, and CBCT systems, facial landmark reliability of less than 0.5 mm can be achieved (Kau et al., 2005, 2007; Liu et al., 2012). Genetic and environmental influences on growth from late childhood to adulthood: a longitudinal study of two Finnish twin cohorts. Forensic Sci. 36, 373380. Am. Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. Psychol. 3D morphometrics of craniofacial dysmorphology reveals sex-specific asymmetries in schizophrenia. Howe, L. J., Sharp, G. C., Hemani, G., Zuccolo, L., Richmond, S., and Lewis, S. J. (2005). Sci. 6:737. doi: 10.3389/fpsyg.2015.00737, Bird, A. High-resolution epigenomic atlas of human embryonic craniofacial development. 214, 291302. Epigenet. (2015). (2012). International anthropometric study of facial morphology in various ethnic groups/races. U.S.A. 114, 1016610171. Last year, the dark-skinned, blue-eyed facial reconstruction of Cheddar Man, a 10,000-year-old British resident, made international headlines and sparked discussions about native identity in a nation grappling with Brexit and issues of migration.. Now, a new exhibit is revealing the faces of seven more ancient locals from the coast of southern You also have the ginger/red hair colour that is quite common on the british isles, most common in Ireland and Scotland, I believe. Aspinall, A., Raj, S., Jugessur, A., Marazita, M., Savarirayan, R., and Kilpatrick, N. (2014). (2009). Much confusion has arisen from the inaccurate use of the terms " Celt " and " Celtic." Genet. doi: 10.1001/jamapediatrics.2017.0778, Munn, L., and Stephan, C. N. (2018). doi: 10.1136/bmjopen-2016-015410, Marazita, M. (2007). Development 126, 48734884. Acad. Cleft lip and palate: understanding genetic and environmental influences. It is therefore important to use causal inference techniques such as epigenetic Mendelian randomization Relton and Davey Smith, 2012) or the Steiger test (Hemani et al., 2017) to orientate the likely directions of effect between phenotypes, epigenetic modifications and gene expression. doi: 10.1007/s00439-016-1754-7, Lippert, C., Sabatini, R., Maher, M. C., Kang, E. Y., Lee, S., Arikan, O., et al. Future, environmental epigenetic studies will show whether particular chemicals map to corresponding sensitive genomic regions. 11, 154158. Indeed, the last Habsburg King of Spain, Charles II, was reported to have had difficulties eating and speaking because of facial deformities. In addition, it is likely that one or more genes influence the whole shape of the face as well as more localized facial regions (Claes et al., 2018). Do mens faces really signal heritable immunocompetence? A Scottish accent is conscious of their Rs and Gs in ing, compared to the Irish accent, which t must use words softly. (2012). eds G. J. Huang, R. S., K.W.L. bioRxiv, Gibney, E., and Nolan, C. (2010). The genes and broad regional associations are shown in Table 2 (ordered by facial feature and chromosome) and Figure 1 (showing facial region).
Accents: Northern Irish Mol. Genet. Genet. Self-perceived attractiveness influences human female preferences for sexual dimorphism and symmetry in male faces. Acad. Finite element modelling of maxillofacial surgery and facial expressionsa preliminary study. Commun. However, previous studies investigating gene-smoking interactions in the etiology of birth defects have produced mixed results (Shi et al., 2008). Hum. doi: 10.1371/journal.pone.0162250, Evans, D. M. (2018). 41, 324330. Different genetic models, genotyping and imputation techniques have been employed and the between-study heterogeneity should be considered. The development of the face involves a coordinated complex series of embryonic events.
What does a (stereo)typical English/Welsh/Scottish/Irish person 289, 4050. J.
Irish Facial Features Sci. (2014). Key transcriptional factors (activators or repressors) have been identified indicating extensive activation during early craniofacial development. Oral Pathol. Richmond, R. C., Sharp, G. C., Herbert, G., Atkinson, C., Taylor, C., Bhattacharya, S., et al. (2016). Schizophr. Psychol. Eur. Neuropharmacol. However, to date one study has indicated that maternal smoking may interact with the GRID2 and ELAVL2 genes resulting in cleft lip and palate (Beaty et al., 2013). Information on an individuals facial morphology can have several important clinical and forensic applications; informing patient specific models, improving and reducing the need for extensive surgical interventions for craniofacial anomalies/trauma, prediction/reconstruction of the facial form from skeletal remains, and identification of suspects from DNA (Stephan et al., 2005; De Greef et al., 2006; Wilkinson et al., 2006; Beldie et al., 2010; Popat et al., 2010, 2012; Richmond et al., 2012; Al Ali et al., 2014a; Shrimpton et al., 2014; Farnell et al., 2017; Richmond S. et al., 2018). (2014). Subclinical features in non-syndromic cleft lip with or without cleft palate (CL/P): review of the evidence that subepithelial orbicularis oris muscle defects are part of an expanded phenotype for CL/P. Indeed, modern day Latin Americans have mixed African, European and Native American ancestry, with genetic admixture highly predictive of physical appearance. Hum. 19:1192. doi: 10.1038/ejhg.2011.110, Brinkley, J. F., Fisher, S., Harris, M. P., Holmes, G., Hooper, J. E., Jabs, E. W., et al. A general model of dioxin contamination in breast milk: results from a study on 94 women from the Caserta and Naples areas in Italy. Face height (28.8%), width of the eyes (10.4%) and prominence of the nose (6.7%) explained 46% of total facial variance (Toma et al., 2012). New developments in: three-dimensional planning for orthognathic surgery. Periderm: Life-cycle and function during orofacial and epidermal development. DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis. Oral Surg. However, large-scale population studies are needed to identify more genetic variants not only in the context of facial shape but general body development with particularly attention to puberty. Int. From birth to adulthood there are significant body and facial changes. Facial phenotypes can influence mate choice and be under selection pressures. Expanding the cleft phenotype: the dental characteristics of unaffected parents of Australian children with non-syndromic cleft lip and palate. Approaching ethical, legal and social issues of emerging forensic DNA phenotyping (FDP) technologies comprehensively: reply to Forensic DNA phenotyping: predicting human appearance from crime scene material for investigative purposes by Manfred Kayser. doi: 10.1016/j.ajodo.2013.01.019, Menezes, R., and Vieira, A. R. (2008). Focusing on specific phenotypes and genetic variants in families will identify additional rare variants should be followed-up with a combination of genotyping and deep re-sequencing of the variants or genes of interest in large numbers of cases and controls. Heredity 105:4. doi: 10.1038/hdy.2010.54, Gluckman, P. D., Hanson, M. A., and Beedle, A. S. (2007). Abbas, H., Hicks, Y., Marshall, D., Zhurov, A. I., and Richmond, S. (2018). Jelenkovic, A., Ortega-Alonso, A., Rose, R. J., Kaprio, J., Rebato, E., and Silventoinen, K. (2011). The developing fetus may be subject to adverse environments at home, in the workplace or through lifestyle activities (smoking, alcohol and drug intake, allergens, paint, pest/weed control, heavy metals, cleaning, body products such as perfumes and creams). Anthropol. 32, 122. The influence of snoring, mouth breathing and apnoea on facial morphology in late childhood: a three-dimensional study. Ireland and their Scottish cousins could have more common ancestry than previously thought. Am. doi: 10.1093/ije/dyg070, Som, P. M., and Naidich, T. P. (2013). Facial fluctuating asymmetry is not associated with childhood ill-health in a large British cohort study. With improving knowledge of the controlling mechanisms for normal and abnormal facial development, it is logical to pursue healthcare strategies in the first instance to prevent craniofacial anomalies arising, with discussion of risks with genetic counseling, possibly future gene therapies and the follow up with minimally invasive or non-surgical, scarless procedures to correct craniofacial anomalies such as cleft lip and palate and control vertical and horizontal growth particularly of the upper and lower jaws and nose. Int. Received: 06 July 2018; Accepted: 20 September 2018;Published: 16 October 2018. Disruptions in the fusion of the facial processes may result in complete or partial clefts of the face, lip and/or palate. Expression of chick Barx-1 and its differential regulation by FGF-8 and BMP signaling in the maxillary primordia. Enhancers have a specific role in the expression of a target gene in different cells, anatomical regions and during different developmental time-points (Visel et al., 2009; Attanasio et al., 2013; Wilderman et al., 2018). U.S.A. 107(Suppl. Despite some evidence for positive correlation between blood and lip tissue DNA methylation (Alvizi et al., 2017; Howe et al., 2018b), the extent to which blood is a suitable proxy is unknown. (2010). For example, there is evidence that nose shape has been under historical selection in certain climates (Weiner, 1954; Zaidi et al., 2017). Asymmetry is preserved in some of these techniques. Genet. A comparison of the prevalence of prenatal alcohol exposure obtained via maternal self-reports versus meconium testing: a systematic literature review and meta-analysis. J. Orthod. Eur. Disentangling these shared pathways can improve understanding of the biological processes that are important during embryonic development. 122, 680690. Homo 61, 191203. Top. Similarly, epigenetic processes may mediate the effects of germline genetic variation. doi: 10.3390/ijerph10115953. LH and AZ wrote the section Environmental Influences. Genet. (2016). Biol. Biol. Why are Irish Pale? Hum. Aesthetic. (2014a). doi: 10.1371/journal.pcbi.1003375, Pickrell, J. K., Berisa, T., Liu, J. Effect of low-dose testosterone treatment on craniofacial growth in boys with delayed puberty. 41, 161176.
Facial doi: 10.1073/pnas.1708207114, Danescu, A., Mattson, M., Dool, C., Diewert, V. M., and Richman, J. M. (2015). However, some common Irish facial features include: a high cheekbones, a long, thin nose, and a sharp chin. The important link between facial variation and nsCL/P is highlighted by a study comparing facial morphologies (linked to genes) of children with nsCL/P and unaffected relatives. For this reason, ancestral markers are often included in facial prediction models (Claes et al., 2014; Ruiz-Linares et al., 2014; Lippert et al., 2017). Sci. 36, 506511. Genet. Irish people sure love their tea. Lancet Oncol. 22, 27352747. Defining facial shape can be undertaken in different ways but it is important to appreciate that there will be associations with not only with other facial features but also body phenotypes and medical conditions. This group is also sometimes referred to as black Irish. 115, 299320. Mendelian randomization: can genetic epidemiology contribute to understanding environmental determinants of disease? Cleft. Simultaneous advances in genotyping technology have enabled the exploration of genetic influences on facial phenotypes, both in the present day and across human history. Prenatal alcohol exposure and facial morphology in a UK cohort. Childbirth 14:127. doi: 10.1186/1471-2393-14-127, Le, T. T., Farkas, L. G., Ngim, R. C., Levin, L. S., and Forrest, C. R. (2002). Heritability maps of human face morphology through large-scale automated three-dimensional phenotyping. doi: 10.1111/adj.12101, Hysi, P. G., Valdes, A. M., Liu, F., Furlotte, N. A., Evans, D. M., Bataille, V., et al.